During 2012, the percentages of U.S. adults aged 18 years or older who used nonvitamin, nonmineral dietary supplements, yoga, massage, meditation, and special diets were higher in metropolitan areas than in nonmetropolitan areas. A greater proportion of adults in nonmetropolitan areas used chiropractic or osteopathic manipulation (9.9%) compared with those in metropolitan areas (7.9%). In both metropolitan and nonmetropolitan areas, dietary supplements had the highest percentage of use (17.9% in metropolitan; 14.2% in nonmetropolitan), and special diets had the lowest percentage of use (3.1% in metropolitan; 1.9% in nonmetropolitan).