Provisional data from NCHS indicate that there were an estimated 100,306 drug overdose deaths in the United States during 12-month period ending in April 2021, an increase of 28.5% from the 78,056 deaths during the same period the year before.

Read more here:
https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2021/20211117.htm
The interactive web dashboard is available at: https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm